Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Hum Brain Mapp. 2012 Dec;33(12):2913-9. doi: 10.1002/hbm.21411. Epub 2011 Oct 14.
Nocturnal enuresis is a common developmental disorder in children, and primary nocturnal enuresis (PNE) is the dominant subtype. The main purpose of this study was to investigate brain functional abnormalities specifically related to motor response inhibition in children with PNE using fMRI in combination with a Go/NoGo task. Twenty-two children with PNE and 22 healthy children, group-matched for age and sex, took part in this experiment. Although no significant between-group differences in task performance accuracy were observed, PNE patients showed significantly longer response times on average. There were several brain regions with reduced activation during motor response inhibition in children with PNE: the bilateral inferior frontal gyri, right superior and middle frontal gyri, right inferior parietal lobe, bilateral cingulate gyri and insula. Our data indicate that response inhibition in children with PNE is associated with a relative lack of or delay in the maturation of prefrontal cortex circuitry that is known to suppress inappropriate responses. This result might give clues to understanding the pathophysiology of PNE.
遗尿症是儿童常见的发育障碍，主要为原发性遗尿症（PNE）。本研究旨在使用 fMRI 结合 Go/NoGo 任务，研究 PNE 儿童与运动反应抑制特异性相关的大脑功能异常。共有 22 名 PNE 患儿和 22 名健康儿童参与了该实验，两组儿童在年龄和性别上相匹配。虽然在任务表现准确性方面没有观察到明显的组间差异，但 PNE 患儿的平均反应时间明显更长。PNE 患儿在运动反应抑制期间，有几个大脑区域的激活减少：双侧额下回、右侧额上回和中回、右侧顶下小叶、双侧扣带回和岛叶。我们的数据表明，PNE 患儿的反应抑制与已知抑制不当反应的前额叶皮层回路的相对不成熟或延迟有关。这一结果可能为理解 PNE 的病理生理学提供线索。
