Zhang Kaihua, Ma Jun, Lei Du, Wang Mengxing, Zhang Jilei, Du Xiaoxia
Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Department of Developmental and Behavioral Pediatrics of Shanghai Children's Medical Center, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China.
Pediatr Res. 2015 Oct;78(4):422-9. doi: 10.1038/pr.2015.120. Epub 2015 Jun 18.
Nocturnal enuresis is a common developmental disorder in children, and primary monosymptomatic nocturnal enuresis (PMNE) is the dominant subtype.
This study investigated brain functional abnormalities that are specifically related to working memory in children with PMNE using function magnetic resonance imaging (fMRI) in combination with an n-back task. Twenty children with PMNE and 20 healthy children, group-matched for age and sex, participated in this experiment.
Several brain regions exhibited reduced activation during the n-back task in children with PMNE, including the right precentral gyrus and the right inferior parietal lobule extending to the postcentral gyrus. Children with PMNE exhibited decreased cerebral activation in the task-positive network, increased task-related cerebral deactivation during a working memory task, and longer response times.
Patients exhibited different brain response patterns to different levels of working memory and tended to compensate by greater default mode network deactivation to sustain normal working memory function. Our results suggest that children with PMNE have potential working memory dysfunction.
夜间遗尿是儿童常见的发育障碍，原发性单症状性夜间遗尿（PMNE）是主要亚型。
本研究采用功能磁共振成像（fMRI）结合n-back任务，调查PMNE儿童中与工作记忆特别相关的脑功能异常。20名PMNE儿童和20名年龄和性别匹配的健康儿童参与了本实验。
在n-back任务期间，PMNE儿童的几个脑区激活减少，包括右侧中央前回和延伸至中央后回的右侧顶下小叶。PMNE儿童在任务阳性网络中脑激活减少，在工作记忆任务期间与任务相关的脑失活增加，且反应时间更长。
患者对不同水平的工作记忆表现出不同的脑反应模式，并倾向于通过更大程度的默认模式网络失活来进行补偿，以维持正常的工作记忆功能。我们的结果表明，PMNE儿童存在潜在的工作记忆功能障碍。
