Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mycoses. 2012 Jul;55(4):357-65. doi: 10.1111/j.1439-0507.2011.02130.x. Epub 2011 Oct 17.
Summary There is a biological plausibility on the link between cystic fibrosis transmembrane conductance regulator (CFTR) mutations and allergic bronchopulmonary aspergillosis (ABPA). The aim of the systematic review was to investigate this link by determining the frequency of CFTR mutations in ABPA. We searched the PubMed and EmBase databases for studies reporting CFTR mutations in ABPA. We pooled the odds ratio (OR) and 95% confidence intervals (CI) from individual studies using both fixed and random effects model. Statistical heterogeneity was evaluated using the I(2) test and the Cochran-Q statistic. Publication bias was assessed using both graphical and statistical methods. Our search yielded four studies (79 ABPA, 268 controls). The odds of encountering CFTR mutation was higher in ABPA compared with the control group (OR 10.39; 95% CI, 4.35-24.79) or the asthma population (OR 5.53; 95% CI 1.62-18.82). There was no evidence of statistical heterogeneity or publication bias. There is a possible pathogenetic link between CFTR mutations and ABPA. However, because of the small numbers of patients, further studies are required to confirm this finding. Future studies should adopt a uniform methodology and should screen for the entire genetic sequence of the CFTR gene.
囊性纤维化跨膜电导调节因子（CFTR）突变与变应性支气管肺曲霉病（ABPA）之间存在生物学相关性。本系统综述的目的是通过确定 CFTR 突变在 ABPA 中的频率来研究这种相关性。我们在 PubMed 和 Embase 数据库中搜索了报告 ABPA 中 CFTR 突变的研究。我们使用固定效应模型和随机效应模型对来自个体研究的比值比（OR）和 95%置信区间（CI）进行了汇总。使用 I(2)检验和 Cochran-Q 统计量评估统计异质性。使用图形和统计方法评估发表偏倚。我们的搜索结果包含四项研究（79 例 ABPA，268 例对照）。与对照组（OR 10.39；95%CI，4.35-24.79）或哮喘人群（OR 5.53；95%CI，1.62-18.82）相比，ABPA 患者中 CFTR 突变的可能性更高。没有证据表明存在统计学异质性或发表偏倚。CFTR 突变与 ABPA 之间可能存在发病机制联系。但是，由于患者数量较少，需要进一步的研究来证实这一发现。未来的研究应采用统一的方法，并应筛查 CFTR 基因的整个遗传序列。
