Technical University of Munich, Munich, Germany.
Int J Antimicrob Agents. 2011 Dec;38 Suppl:21-35. doi: 10.1016/j.ijantimicag.2011.09.003. Epub 2011 Oct 14.
Uncomplicated urinary tract infections (UTIs) in otherwise healthy premenopausal women are one of the most frequent infections in the community. Therefore any improvement in management will have a high impact not only on the quality of life of the individual patient but also on the health system. In placebo-controlled studies antimicrobial treatment was significantly more effective than placebo, but on the other hand showed more adverse events. The choice of antibiotic depends on the spectrum and susceptibility patterns of the uropathogens, its effectiveness for this indication, its tolerability, its collateral effects and cost. After a systematic literature search, recommendations for empiric treatment of acute uncomplicated cystitis and acute uncomplicated pyelonephritis and for follow-up strategies were developed.
在健康的绝经前女性中，单纯性尿路感染 (UTI) 是社区中最常见的感染之一。因此，任何管理上的改进不仅将对个体患者的生活质量产生重大影响，而且对卫生系统也将产生重大影响。在安慰剂对照研究中，抗菌治疗明显比安慰剂更有效，但另一方面显示出更多的不良反应。抗生素的选择取决于尿路病原体的光谱和敏感性模式、其对该适应症的有效性、其耐受性、其副作用和成本。在系统的文献检索之后，制定了用于急性单纯性膀胱炎和急性单纯性肾盂肾炎的经验性治疗以及随访策略的建议。
