Biochemie-Zentrum der Universität Heidelberg, INF328, Heidelberg, Germany.
Nat Struct Mol Biol. 2013 Jul;20(7):776-80. doi: 10.1038/nsmb.2605.
Signal recognition particle, MinD and BioD (SIMIBI)-type nucleoside triphosphate-binding proteins are an ancient subfamily of nucleotide-binding proteins that serve in a wide range of cellular processes. Notably, this class comprises dimeric ATPases as well as GTPases (SIMIBI 'twins') and a subset of SIMIBI-type proteins, including SRP GTPases, MinD-type ATPases and the Get3 ATPase, is essential to protein targeting and localization. Here, we define common mechanistic principles and differences for these SIMIBI proteins.
信号识别颗粒、MinD 和 BioD（SIMIBI）-型核苷三磷酸结合蛋白是一类广泛存在于多种细胞过程中的核苷酸结合蛋白的古老亚家族。值得注意的是，该类蛋白包含二聚体 ATP 酶和 GTP 酶（SIMIBI“双胞胎”），以及包括 SRP GTP 酶、MinD 型 ATP 酶和 Get3 ATP 酶在内的 SIMIBI 型蛋白亚组，对蛋白质靶向和定位至关重要。在此，我们为这些 SIMIBI 蛋白定义了共同的机制原则和差异。
