Moore J N, Steiss J, Nicholson W E, Orth D N
Endocrinology. 1979 Mar;104(3):576-82. doi: 10.1210/endo-104-3-576.
In the horse, a syndrome of hirsutism, hyperglycemia, glucosuria, polydipsia, polyuria, polyphagia, and progressive debilitation has been recognized. Most often the syndrome has been associated with adenomas of the pars intermedia of the pituitary and bilateral adrenal hyperplasia or nodular hyperplasia involving primarily the zona fasciculata. Previously, the syndrome has been ascribed to compression of the hypothalamus by an expanding but functionally inactive pituitary neoplasm. In the present case, with RIA determination of plasma ACTH concentrations, the syndrome was ascribed to pituitary ACTH-dependent hyperadrenocorticism and likened to human Cushing's disease.
在马身上，已确认存在多毛症、高血糖、糖尿、烦渴、多尿、多食以及进行性衰弱的综合征。该综合征最常与垂体中间部腺瘤以及主要累及束状带的双侧肾上腺增生或结节性增生相关。此前，该综合征被归因于不断增大但功能无活性的垂体肿瘤对下丘脑的压迫。在本病例中，通过放射免疫分析法测定血浆促肾上腺皮质激素（ACTH）浓度，该综合征被归因于垂体促肾上腺皮质激素依赖性肾上腺皮质功能亢进，并被认为与人类库欣病相似。
