一匹患有库欣氏病的马。

[A horse with Cushing's disease].

作者信息

van der Kolk J H, Klein W R, van der Putten S W, Mol J A

机构信息

Vakgroep Inwendige Ziekten en Voeding der Grote Huisdieren, Faculteit Diergeneeskunde, Utrecht.

出版信息

Tijdschr Diergeneeskd. 1991 Jul 1;116(13):670-5.

PMID:1650504

Abstract

A thirteen-year-old Dutch warmblooded mare was referred to the Faculty of Veterinary Medicine because of a sinusitis. She was thin with a potbellied appearance. Her coat was dull with long wavy hair. Unilateral (left) purulent nasal discharge was evident. A cbc revealed leucopenia (3.9 G.L.-1) and plasma biochemical analysis revealed a plasma glucose concentration of 10.1 mmol.L-1. Thermostable alkaline phosphatase (at 65 degrees C during 2 minutes) could not be demonstrated. Basal plasma cortisol concentration was lowered (114 nmol.L-1) and basal plasma ACTH concentration was highly elevated (815 pg.ml-1), indicating adrenocortical insufficiency. A dexamethasone-suppression test was performed by intramuscular administering of 10 mg of dexamethasone showing a suppression of 32% instead of at least 50%. At necropsy a pituitary pars intermedia adenoma was found.

摘要

一匹13岁的荷兰温血母马因鼻窦炎被转诊至兽医学院。它体型消瘦，腹部突出。毛发暗淡且长而卷曲。明显可见单侧（左侧）脓性鼻分泌物。全血细胞计数显示白细胞减少（3.9×10⁹/L），血浆生化分析显示血浆葡萄糖浓度为10.1 mmol/L。未检测到耐热碱性磷酸酶（65℃ 2分钟）。基础血浆皮质醇浓度降低（114 nmol/L），基础血浆促肾上腺皮质激素浓度显著升高（815 pg/ml），提示肾上腺皮质功能不全。通过肌肉注射10 mg地塞米松进行地塞米松抑制试验，结果显示抑制率为32%，而非至少50%。尸检发现垂体中间部腺瘤。