Zull J E, Smith S K
Department of Biology, Case Western Reserve University, Cleveland, OH 44106.
Trends Biochem Sci. 1990 Jul;15(7):257-61. doi: 10.1016/0968-0004(90)90048-g.
We have noted that the sense-antisense relationships inherent in the genetic code divide the amino acids into three separate groups. The nature of the amino acids in each group may allow the polypeptides coded by the antisense strand to retain the secondary structure patterns of the translated strand. Also, this relationship requires all but eight of the codons in the eukaryotic code and all but four in the mitochondrial code. Thus, genetic code redundancy could be related to evolutionary pressure toward retention of protein structural information in both strands of DNA.
我们已经注意到，遗传密码中固有的 sense-antisense 关系将氨基酸分为三个独立的组。每组中氨基酸的性质可能使反义链编码的多肽保留翻译链的二级结构模式。此外，这种关系在真核生物密码子中除了八个密码子外适用，在线粒体密码子中除了四个密码子外适用。因此，遗传密码的冗余可能与在 DNA 两条链中保留蛋白质结构信息的进化压力有关。
