Hull M T, Warfel K A
Ultrastruct Pathol. 1987;11(1):29-38. doi: 10.3109/01913128709023180.
Eight mucinous carcinomas of the breast were studied by light microscopy and immunohistochemistry; one was studied by electron microscopy. All 8 cases had abundant, relatively clear cytoplasm that contained mucin. Cells were argyrophil positive and argentaffin negative. Eight cases were positive for neuron specific enolase (NSE), 5 cases for serotonin, 1 case for serotonin and somatostatin and 2 cases for serotonin, somatostatin, and gastrin. None had clinical evidence of abnormal neuroendocrine function. Three patients had axillary lymph node metastases. Only 1 of 5 patients in whom there was clinical followup died of her disease. Electron microscopy of one case showed abundant intracytoplasmic and extracellular mucin, round and pleomorphic dense-core granules, numerous cell processes, and aggregates of intermediate filaments. These cases expand the histologic spectrum of breast carcinomas which may show neuroendocrine differentiation.
对8例乳腺黏液癌进行了光镜和免疫组化研究；对1例进行了电镜研究。所有8例均有丰富、相对清亮的含黏液的细胞质。细胞嗜银染色阳性，亲银染色阴性。8例神经元特异性烯醇化酶（NSE）阳性，5例血清素阳性，1例血清素和生长抑素阳性，2例血清素、生长抑素和胃泌素阳性。均无神经内分泌功能异常的临床证据。3例有腋窝淋巴结转移。5例有临床随访的患者中仅1例死于该病。1例的电镜检查显示有丰富的胞质内和细胞外黏液、圆形和多形性致密核心颗粒、许多细胞突起以及中间丝聚集。这些病例扩展了可能显示神经内分泌分化的乳腺癌的组织学谱。
