丙型肝炎病毒特异性免疫的最新进展。
Update on hepatitis C virus-specific immunity.
机构信息
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Curr Opin HIV AIDS. 2011 Nov;6(6):559-65. doi: 10.1097/COH.0b013e32834b879e.
PURPOSE OF REVIEW
The goal of this study is to review key recent findings related to the immunopathogenesis of hepatitis C virus (HCV) infection, especially in regards to T lymphocytes. It aims to complement other reviews in this issue on the roles of host genetics (IL-28B), acute HCV infection (when disease outcome is determined) and other factors that may influence fibrosis progression (microbial translocation). The main focus is on specific immunity and T cells in the context of success and failure to control viral infection.
RECENT FINDINGS
This review focuses on two areas of intense interest in the recent literature: the relationship between the human leukocyte antigen (HLA), class I-restricted T-cell responses and the evolution of the virus and the role of inhibitory markers on T cells in the immunopathogenesis of HCV. When appropriate, we compare findings from studies of HIV-specific immunity.
SUMMARY
From examining the virus and the mutational changes associated with T-cell responses and from analyzing the markers on T cells, there have been numerous advances in the understanding of immune evasion mechanisms employed by HCV.
目的综述
本研究旨在综述丙型肝炎病毒（HCV）感染免疫发病机制的关键最新发现，特别是与 T 淋巴细胞相关的发现。它旨在补充本期其他关于宿主遗传学（IL-28B）、急性 HCV 感染（决定疾病结局时）和其他可能影响纤维化进展的因素（微生物易位）的作用的综述。主要重点是在成功和未能控制病毒感染的情况下，特异性免疫和 T 细胞的作用。
最近的发现
本综述侧重于近期文献中两个极感兴趣的领域：人类白细胞抗原（HLA）与 I 类限制的 T 细胞反应之间的关系，以及病毒的演变，以及抑制性标记物在 HCV 免疫发病机制中的作用。在适当的情况下，我们比较了 HIV 特异性免疫研究的结果。
总结
通过检查与 T 细胞反应相关的病毒和突变变化，并分析 T 细胞上的标记物，我们对 HCV 所采用的免疫逃逸机制有了许多新的认识。
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