Department of Hepatology, Imperial College London, Norfolk Place, London W2 1PG, UK.
Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, UK.
J Gen Virol. 2011 Oct;92(Pt 10):2227-2236. doi: 10.1099/vir.0.033910-0. Epub 2011 Jul 20.
New insights into the early viral evolution and cellular immune response during acute hepatitis C virus (HCV) infection are being gained following a global outbreak in human immunodeficiency virus-1 (HIV)-positive men who have sex with men. Cross-sectional and longitudinal sequence analysis at both the population and individual level have facilitated tracking of the HCV epidemic across the world and enabled the development of tests of viral diversity in individual patients in order to predict spontaneous clearance of HCV and response to treatment. Immunological studies in HIV-positive cohorts have highlighted the role of the CD4+ T-cell response in the control of early HCV infection and will increase the opportunity for the identification of protective epitopes that could be used in future vaccine development.
在人类免疫缺陷病毒 1（HIV）阳性的男男性行为者中发生全球疫情后，人们对急性丙型肝炎病毒（HCV）感染期间的早期病毒演变和细胞免疫反应有了新的认识。在人群和个体水平上进行的横断面和纵向序列分析，有助于追踪全球 HCV 流行情况，并开发了用于预测 HCV 自发清除和对治疗反应的个体患者病毒多样性检测。在 HIV 阳性队列中的免疫研究强调了 CD4+ T 细胞反应在控制早期 HCV 感染中的作用，并将增加鉴定保护性表位的机会，这些表位可用于未来的疫苗开发。
