Department of Pathology, Singapore General Hospital, Singapore.
Pathology. 2011 Dec;43(7):673-81. doi: 10.1097/PAT.0b013e32834bf5d2.
Lymphomas of natural killer (NK) and T cell lineages are uncommon disorders, although as a group they are more usually encountered in Asia compared to Western populations. In part due to their rarity, diagnosis and classification of T cell lymphomas often pose a challenge to clinicians and pathologists. Although there are morphological features that are characteristic of certain subtypes, correct classification of NK and T cell neoplasms relies heavily on the immunophenotype. With few exceptions, non-random genetic alterations such as translocations are less often seen in T cell neoplasms, adding to the diagnostic difficulty. Given these limitations, pathological diagnosis and classification of NK and T cell lymphomas are anything but straightforward. This paper attempts to present a practical algorithmic approach for the general pathologist who is confronted with these neoplasms.
自然杀伤 (NK) 细胞和 T 细胞谱系淋巴瘤是不常见的疾病，尽管与西方人群相比，它们在亚洲更为常见。部分由于其罕见性，T 细胞淋巴瘤的诊断和分类常常对临床医生和病理学家构成挑战。尽管存在某些亚型特有的形态学特征，但 NK 和 T 细胞肿瘤的正确分类在很大程度上依赖于免疫表型。除了少数例外情况，非随机的遗传改变，如易位，在 T 细胞肿瘤中较少见，这增加了诊断的难度。鉴于这些局限性，NK 和 T 细胞淋巴瘤的病理诊断和分类绝非易事。本文试图为遇到这些肿瘤的普通病理学家提供一种实用的算法方法。
