Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
Planta Med. 2012 Jan;78(2):148-53. doi: 10.1055/s-0031-1280289. Epub 2011 Oct 14.
Two new 2-arylbenzofuran neolignans and a new benzophenanthridine alkaloid, together with six known benzophenanthridine alkaloids, namely, decarine, norchelerythrine, dihydrochelerythrine, 6-acetonyldihydrochelerythrine, tridecanonchelerythrine, and 6-acetonyldihydronitidine, have been isolated from the MeOH extract of the roots of Zanthoxylum capense. Their structures were elucidated by means of spectroscopic techniques including 2D NMR experiments. All the isolated compounds were evaluated for their in vitro antibacterial activity against gram-positive and gram-negative bacteria. Some compounds showed significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 μg/mL.
从山蒟根的甲醇提取物中分离得到两个新的 2-芳基苯并呋喃型新木脂素和一个新的苯并菲啶生物碱，以及六个已知的苯并菲啶生物碱，即 decarine、norchelerythrine、dihydrochelerythrine、6-acetonyldihydrochelerythrine、tridecanonchelerythrine 和 6-acetonyldihydronitidine。通过包括 2D NMR 实验在内的光谱技术手段阐明了它们的结构。所有分离得到的化合物均进行了体外抗菌活性评估，针对革兰氏阳性菌和革兰氏阴性菌。一些化合物对金黄色葡萄球菌 ATCC 6538 表现出显著的抑制活性，MIC 值范围为 12.5 至 50 μg/mL。
