从 Lecoy.exOliv. 的根部提取的双苯并菲啶生物碱

Benzophenanthridine alkaloids from the roots of Lecoy.ex Oliv.

机构信息

a Department of Pharmacy, Wuhan first Hospital , Wuhan , Hubei , China.

出版信息

Nat Prod Res. 2019 Oct;33(20):2964-2969. doi: 10.1080/14786419.2018.1512991. Epub 2018 Oct 11.

DOI:10.1080/14786419.2018.1512991

Abstract

A new benzophenanthridine alkaloid, 2,3,9-trimethoxy-7,8-methylenedioxy-5-methylbenzo[c]-6(5H) phenanthridone () and a benzophenanthridine alkaloid first found from natural sources, 2,3-dimethoxy-7,8- methylenedioxy-5-methylbenzo[c]-6(5H)- phenanthridone () together with two known benzophenanthridine alkaloids, Dihydrosanguinarine () and Dihydrochelilutine () were isolated from the roots of Thalictrum microgynum Lecoy.ex Oliv. The structures of and were elucidated using various spectroscopic techniques including HRESIMS and 1 D and 2 D NMR. Antibacterial activity of these compounds were tested. Compound , and showed antibacterial activity against with MIC values of 50, 100, 25 μg/mL, respectively.

摘要

从獐牙菜属植物纤细獐牙菜 Thalictrum microgynum Lecoy.ex Oliv. 的根部分离得到了一个新的苯并菲啶生物碱 2,3,9-三甲氧基-7,8-亚甲二氧基-5-甲基苯并[c]-6(5H)-菲啶酮 ()，以及一个首次从天然来源中发现的苯并菲啶生物碱 2,3-二甲氧基-7,8-亚甲二氧基-5-甲基苯并[c]-6(5H)-菲啶酮 ()，此外还分离得到了另外两个已知的苯并菲啶生物碱二氢血根碱 ()和二氢白屈菜红碱 ()。通过各种光谱技术，包括高分辨质谱（HRESIMS）和 1D 和 2D NMR，阐明了化合物和的结构。对这些化合物进行了抗菌活性测试。化合物、和对表现出抗菌活性，MIC 值分别为 50、100 和 25μg/mL。