Gadzhanova Svetla, Gillies Malcolm, Roughead Elizabeth, Zuo Yeqin
Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, The University of South Australia.
Aust Fam Physician. 2011 Oct;40(10):811-5.
To examine initiation and prescribing patterns of metformin-glibenclamide and metformin-rosiglitazone fixed dose combination products within the Australian veteran population.
A retrospective observational study using Department of Veterans' Affairs pharmacy claims data. We examined overall trends in the utilisation and proportion of patients who had been previously dispensed both, one, or none of the individual ingredient products before initiating combination products.
Of metformin-glibenclamide initiations, 9% involved a switch from metformin and glibenclamide as separate products, while 22% had used neither metformin nor a sulfonylurea. Thirty percent of metformin-rosiglitazone initiations involved a switch from both individual products, while in 10% neither metformin nor thiazolidinedione had been dispensed.
A minority of veterans started taking the combination products after being stabilised on the individual products; many had no prior history of oral hypoglycaemic use. This prescribing may lead to wastage if combination medications are poorly tolerated or, more importantly, may cause adverse events.
研究澳大利亚退伍军人中二甲双胍-格列本脲和二甲双胍-罗格列酮固定剂量复方制剂的起始用药及处方模式。
一项使用退伍军人事务部药房报销数据的回顾性观察研究。我们研究了在开始使用复方制剂之前，曾被配给过两种单一成分产品之一或两种都未被配给过的患者的使用总体趋势和比例。
在开始使用二甲双胍-格列本脲的患者中，9%是从单独使用二甲双胍和格列本脲转换而来，而22%既未使用过二甲双胍也未使用过磺脲类药物。开始使用二甲双胍-罗格列酮的患者中，30%是从两种单一成分产品转换而来，而10%既未配给过二甲双胍也未配给过噻唑烷二酮类药物。
少数退伍军人在单一成分产品使用稳定后开始服用复方制剂；许多人既往无口服降糖药使用史。如果复方药物耐受性差，这种处方可能导致浪费，或者更重要的是，可能会引起不良事件。
