具有杀菌活性的苯并咪唑新杂环衍生物——VII——5-位带有不同取代基的2-（5'-硝基-2'-呋喃基或2'-噻吩基）苯并咪唑
New heterocyclic derivatives of benzimidazole with germicidal activity--VII--2-(5'-nitro-2'-furyl or 2'-thienyl) benzimidazoles with different substituents in the 5-position.
作者信息
Pedini M, De Meo G, Ricci A, Bastianini L, Jacquignon P
机构信息
Sezione di Biochimica e Chimica Medica, Università degli Studi di Perugia, Italia.
出版信息
Farmaco. 1990 Mar;45(3):303-12.
PMID:2200421
Abstract
In continuation of our previous research, the synthesis of 13 2-(5'-nitro-2'-furyl or 2'-thienyl) benzimidazoles with different substituents in 5 position is described. The new compounds were tested in vitro against 5 (Gram+) and 4 (Gram-) strains and a mycete Candida Albicans. All the derivatives showed a certain degree of antibacterial and antimycotic activity, which in some cases was fairly good.
摘要
在我们先前研究的延续中，描述了在5位带有不同取代基的13种2 -（5'-硝基-2'-呋喃基或2'-噻吩基）苯并咪唑的合成。新化合物针对5种革兰氏阳性菌、4种革兰氏阴性菌菌株以及一种真菌白色念珠菌进行了体外测试。所有衍生物均表现出一定程度的抗菌和抗真菌活性，在某些情况下活性相当良好。
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