Alunni Bistocchi G, De Meo G, Pedini M, Ricci A, Pitzurra M, Cavallo R, Sposini T, Piccardi C, Jacquignon P
Farmaco Sci. 1984 Aug;39(8):660-73.
Study of the microbiological activity of 5-fluoro-(2'-nitrofuryl)-2-benzimidazole F-O-NO2 (I) was continued. The substance was tested on cultures of B. subtilis and C. albicans. From the microbial strains studied, the mortality rate, the minimum inhibitory and bacterial concentrations and the cytotoxicity were determined. The action mechanism was studied using tritiated leucin, uracil and thymidine. Acute toxicity in the mouse (DL50 = 275 mg/kg) was also determined. The germicidal activity of (II), homologous N-ethyl derivative of (I), was also studied. On the basis of the results obtained, a possible mechanism of action of compound (I) is discussed.
5-氟-(2'-硝基呋喃基)-2-苯并咪唑F-O-NO₂（I）的微生物活性研究仍在继续。该物质在枯草芽孢杆菌和白色念珠菌培养物上进行了测试。从所研究的微生物菌株中，测定了死亡率、最小抑菌浓度和细菌浓度以及细胞毒性。使用氚标记的亮氨酸、尿嘧啶和胸腺嘧啶研究了作用机制。还测定了该物质对小鼠的急性毒性（半数致死剂量DL50 = 275毫克/千克）。此外，还研究了（I）的同系物N-乙基衍生物（II）的杀菌活性。根据所得结果，讨论了化合物（I）可能的作用机制。
