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关节抽吸和皮质类固醇注射治疗膝骨关节炎的效果。

The effect of joint aspiration and corticosteroid injections in osteoarthritis of the knee.

机构信息

Western Hospital, Melbourne, Australia.

出版信息

Int J Rheum Dis. 2011 Oct;14(4):384-9. doi: 10.1111/j.1756-185X.2011.01631.x. Epub 2011 Aug 31.

Abstract

AIM

To evaluate the benefits of knee joint aspiration and injection in knee osteoarthritis (OA).

METHODS

A retrospective, pilot study involved 110 patients with knee OA from a dedicated OA clinic in a Melbourne tertiary hospital from 2007 to 2009. Only those who had completed two Multiple Attribute Prioritization Tool (MAPT) questionnaires within 6 months of the initial review were included. The MAPT was designed to help prioritise patients on orthopedic waiting lists. Three groups were analyzed: patients who had no corticosteroid injection or aspiration, patients who received corticosteroid injections, and patients who received both joint aspiration with corticosteroid injections.

RESULTS

Patients who had both joint aspiration and injection reported an improvement in pain compared with those who had no injection (56.3%vs. 32.2%, P = 0.03). Those who had joint injections also did better than those without injection (62.7%vs. 32.2%, P = 0.001). Reduced analgesia use was noted in 12.5% of patients with aspiration and injection compared with 1.7% with no injection or aspiration (P = 0.03). Improved walking distance was noted in 22.4% of patients who had injections compared with 8.5% of patients with no injections (P = 0.03). No significant differences in MAPT scores among the different treatment groups were noted.

CONCLUSION

This pilot study appears to show a beneficial trend in giving corticosteroid injections and to aspirate the knee in OA patients. Further studies are needed to address the mechanical benefits, quadriceps strengthening and pain reduction with knee aspiration, as well as the effects that different volumes of fluid may have on knee mechanics and symptoms.

摘要

目的

评估膝关节抽吸和注射在膝骨关节炎(OA)中的益处。

方法

这是一项回顾性、试点研究,纳入了 2007 年至 2009 年期间墨尔本一家三级医院专门的 OA 诊所的 110 例膝 OA 患者。仅纳入了在初次就诊后 6 个月内完成了两次多属性优先排序工具(MAPT)问卷的患者。MAPT 旨在帮助对骨科等候名单上的患者进行优先排序。分析了三组患者:未接受皮质类固醇注射或抽吸的患者、接受皮质类固醇注射的患者和同时接受关节抽吸加皮质类固醇注射的患者。

结果

与未接受注射的患者相比,同时接受关节抽吸和注射的患者报告疼痛改善(56.3%对 32.2%,P=0.03)。接受关节注射的患者也比未接受注射的患者表现更好(62.7%对 32.2%,P=0.001)。与未接受注射或抽吸的患者(1.7%)相比,接受抽吸和注射的患者中有 12.5%的患者减少了镇痛药物的使用(P=0.03)。与未接受注射的患者(8.5%)相比,接受注射的患者中有 22.4%的患者行走距离改善(P=0.03)。不同治疗组之间的 MAPT 评分无显著差异。

结论

本试点研究似乎表明,在 OA 患者中给予皮质类固醇注射和抽吸膝关节有有益的趋势。需要进一步研究以确定膝关节抽吸的机械效益、股四头肌强化和疼痛减轻,以及不同容量的液体可能对膝关节力学和症状的影响。

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