State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Sichuan University, Chengdu 610065, China.
Langmuir. 2011 Dec 6;27(23):14401-7. doi: 10.1021/la2028803. Epub 2011 Nov 9.
This article studies the self-assembly of alginate-graft-poly(ethylene glycol) (Alg-g-PEG) and α-cyclodextrin (α-CD) in aqueous solution. It was found that they could form hollow spheres because of the formation of coil-rod Alg-g-PEG/α-CD inclusion complexes. In these Alg-g-PEG/α-CD complexes, the α-CDs are stacked along the PEG side chains to form a rod block, and alginate main chains act as a coil block. More rod-like blocks in Alg-g-PEG/α-CD favor the formation of small assemblies. The assemblies of Alg-g-PEG/α-CD show a dependence on concentration, temperature, pH, and salt concentration. At low concentration (below 0.125%) or high temperature (above 32 °C), Alg-g-PEG/α-CD particles were unstable and disrupted. Increasing the salt or decreasing the pH resulted in the aggregation of Alg-g-mPEG/α-CD particles, as detected by the increase in the recorded hydrodynamic diameter (D(h)).
本文研究了海藻酸钠接枝聚乙二醇（Alg-g-PEG）和α-环糊精（α-CD）在水溶液中的自组装。研究发现，由于形成了螺旋-棒状Alg-g-PEG/α-CD 包结复合物，它们可以形成中空球体。在这些 Alg-g-PEG/α-CD 复合物中，α-CDs 沿着 PEG 侧链堆积形成棒状嵌段，而海藻酸钠主链则作为一个线圈嵌段。Alg-g-PEG/α-CD 中更多的棒状嵌段有利于小组装体的形成。Alg-g-PEG/α-CD 的组装体依赖于浓度、温度、pH 值和盐浓度。在低浓度（低于 0.125%）或高温（高于 32°C）下，Alg-g-PEG/α-CD 颗粒不稳定并破裂。增加盐或降低 pH 值会导致 Alg-g-mPEG/α-CD 颗粒聚集，这可以通过记录的水动力直径（D(h)）增加来检测到。
