Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Carbohydr Polym. 2013 Jan 30;92(1):523-8. doi: 10.1016/j.carbpol.2012.09.053. Epub 2012 Oct 2.
A kind of novel magnetic hollow spheres was prepared by encapsulating magnetofluid into polymeric hollow spheres. Polymeric hollow nanospheres were constructed by self-assembly of rod-coil complexes, in which the rod-like segments were formed by inclusion of α-cyclodextrins (α-CD) and grafting poly(ethylene glycol) (PEG) chains of chitosan-graft-PEG (CS-g-PEG). Structural characteristics of CS-g-PEG/α-CD hollow spheres were investigated in detail by NMR, XRD, TEM, etc. Furthermore, those hollow spheres showed a pH responsive property which induced a considerable change of their radius. Magnetofluid was physically entrapped into the empty domain while hollow spheres were formed, it was found that the hollow spheres can encapsulate large quantities of magnetofluid and the encapsulated magnetofluid still possess magnetic responsiveness properties. We expect that this strategy may be served as a novel and more straightforward approach to obtain magnetic hollow spheres for biomedical application.
一种新型磁性中空球是通过将磁流体封装到聚合物中空球中而制备的。聚合物中空纳米球是通过棒-环配合物的自组装构建的，其中棒状部分是由α-环糊精（α-CD）包合和接枝壳聚糖接枝聚乙二醇（CS-g-PEG）的聚乙二醇（PEG）链形成的。通过 NMR、XRD、TEM 等对 CS-g-PEG/α-CD 中空球的结构特征进行了详细研究。此外，这些中空球表现出 pH 响应特性，导致其半径发生相当大的变化。在形成中空球的同时，将磁流体物理地包封在空穴中，结果发现中空球可以包封大量的磁流体，并且包封的磁流体仍然具有磁响应特性。我们期望这种策略可以作为一种新颖且更直接的方法来获得用于生物医学应用的磁性中空球。
