Department of Psychology, Drexel University, Philadelphia, PA 19102, USA.
J Consult Clin Psychol. 2011 Dec;79(6):772-6. doi: 10.1037/a0025714. Epub 2011 Oct 17.
To investigate whether, at study entry, (a) weight suppression (WS), the difference between highest past adult weight and current weight, prospectively predicts time to first full remission from bulimia nervosa (BN) over a follow-up period of 8 years, and (b) weight change over time mediates the relationship between WS and time to first full remission.
A well-characterized sample of women with BN (N = 110; M age = 25.58 years, SD = 6.48) from the Massachusetts General Hospital Longitudinal Study of Eating Disorders was interviewed at 6-12 month intervals over 8 years. The main outcome measure, a "time to first full remission" variable, was based on psychiatric status ratings generated from the Eating Disorders Longitudinal Interval Follow-up Evaluation.
WS was significantly associated with time to first full remission (p = .01; hazard ratio = .89; 95% confidence interval [0.82, 0.97]), indicating that women who were more weight suppressed at study entry took longer to recover. Weight change did not mediate the relationship between WS and time to remission.
Results add to a growing body of evidence that WS predicts maintenance of BN symptoms and extend previous short-term findings by demonstrating, over a period of approximately 8 years, that WS predicts longer time to first full remission. Beyond absolute weight status, WS level may significantly inform the treatment of BN.
研究在研究开始时，（a）体重抑制（WS），即过去成年最高体重与当前体重的差异，是否能够预测从神经性贪食症（BN）首次完全缓解的时间，随访期为 8 年，以及（b）体重随时间的变化是否调节 WS 与首次完全缓解时间之间的关系。
对来自马萨诸塞州综合医院饮食失调纵向研究的具有良好特征的 BN 女性样本（N=110；M 年龄=25.58 岁，SD=6.48）进行了 8 年的 6-12 个月间隔访谈。主要结局指标，即“首次完全缓解时间”变量，基于从饮食失调纵向间隔随访评估中生成的精神状态评分。
WS 与首次完全缓解时间显著相关（p=0.01；风险比=0.89；95%置信区间[0.82，0.97]），表明在研究开始时 WS 较高的女性恢复时间更长。体重变化并没有调节 WS 与缓解时间之间的关系。
研究结果增加了越来越多的证据表明 WS 预测 BN 症状的维持，并通过在大约 8 年的时间内证明 WS 预测首次完全缓解的时间更长，扩展了之前的短期研究结果。除了绝对体重状况外，WS 水平可能会对 BN 的治疗提供重要信息。
