Institute of Bioinformatics, Faculty of Medicine, University of Muenster, Niels Stensen Str, 14, 48149 Muenster, Germany.
Biol Direct. 2011 Oct 17;6:54. doi: 10.1186/1745-6150-6-54.
The vertebrate globin gene repertoire consists of seven members that differ in terms of structure, function and phyletic distribution. While hemoglobin, myoglobin, cytoglobin, and neuroglobin are present in almost all gnathostomes examined so far, other globin genes, like globin X, are much more restricted in their phyletic distribution. Till today, globin X has only been found in teleost fish and Xenopus. Here, we report that globin X is also present in the genomes of the sea lamprey, ghost shark and reptiles. Moreover, the identification of orthologs of globin X in crustacean, insects, platyhelminthes, and hemichordates confirms its ancient origin.
脊椎动物球蛋白基因库由七个成员组成，它们在结构、功能和系统发生分布上有所不同。虽然血红蛋白、肌红蛋白、细胞球蛋白和神经球蛋白几乎存在于迄今为止检查过的所有有颌类动物中，但其他球蛋白基因，如球蛋白 X，在系统发生分布上受到更大的限制。直到今天，球蛋白 X 只在硬骨鱼和非洲爪蟾中发现。在这里，我们报告说球蛋白 X 也存在于七鳃鳗、幽灵鲨和爬行动物的基因组中。此外，在甲壳动物、昆虫、扁形动物和半索动物中鉴定出球蛋白 X 的同源物证实了它的古老起源。
