Department of Children Health and Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
Br J Nutr. 2012 Jul;108(2):357-62. doi: 10.1017/S0007114511005666. Epub 2011 Oct 18.
In the present study, we investigated the prevalence of anaemia and Fe deficiency anaemia (IDA) and explored the relationship between Helicobacter pylori infection and IDA in adolescent girls. A total of 1037 adolescent girls from Suihua, China were enrolled. Hb, serum ferritin (SF), serum transferrin receptor (sTfR) and serum IgG antibodies to H. pylori were measured. Participants with IDA and co-existing H. pylori infection (n 80) who had an intake of >25 mg/d of Fe were assigned randomly to the intervention and control groups. Patients in the intervention group were administered a 12-week course of oral EDTA-Na-Fe (60 mg Fe/dose, three times a week) and a 2-week course of colloidal bismuth subcitrate, amoxicillin and metronidazole. Subjects in the control group were administered EDTA-Na-Fe alone. Hb, SF and sTfR were reassessed 3 months after the 12-week regimen ended. Prevalence of anaemia, Fe deficiency (defined as SF < 12·0 μg/l), IDA and H. pylori infection in the population of 1037 was 19.5, 40.4, 17.1 and 31.2 %, respectively. The prevalence of H. pylori infection in the IDA group was 46.9 %, while the non-anaemic group had 28.1 % prevalence. A significant increase in Hb and SF and a decrease in sTfR value were found in the intervention group and the H. pylori-negative group. Findings suggest that IDA is still one of the prominent problems in adolescent girls. There is an association between H. pylori infection and IDA. Treatment of H. pylori infection is associated with a more rapid response to oral Fe therapy.
在本研究中，我们调查了贫血和缺铁性贫血（IDA）的流行情况，并探讨了青少年女性中幽门螺杆菌感染与 IDA 之间的关系。共纳入中国绥化的 1037 名青少年女性。测量了血红蛋白（Hb）、血清铁蛋白（SF）、血清转铁蛋白受体（sTfR）和血清 IgG 抗幽门螺杆菌抗体。将患有 IDA 和并存幽门螺杆菌感染（n=80）且铁摄入量>25mg/d 的参与者随机分配至干预组和对照组。干预组患者接受为期 12 周的口服 EDTA-Na-Fe（60mg Fe/剂量，每周 3 次）和为期 2 周的胶体次枸橼酸铋、阿莫西林和甲硝唑治疗。对照组患者仅给予 EDTA-Na-Fe。在 12 周疗程结束后 3 个月评估 Hb、SF 和 sTfR。在 1037 名人群中，贫血、铁缺乏（定义为 SF<12.0μg/l）、IDA 和幽门螺杆菌感染的患病率分别为 19.5%、40.4%、17.1%和 31.2%。IDA 组的幽门螺杆菌感染率为 46.9%，而非贫血组的感染率为 28.1%。干预组和幽门螺杆菌阴性组的 Hb 和 SF 显著增加，sTfR 值降低。结果表明，IDA 仍然是青少年女性的突出问题之一。幽门螺杆菌感染与 IDA 之间存在关联。治疗幽门螺杆菌感染与口服铁治疗的快速反应有关。
