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在免疫功能正常的患者中,行椎间盘造影术后发现葡萄牙念珠菌。

Candida lusitaniae discitis after discogram in an immunocompetent patient.

机构信息

Department of Orthopaedic Surgery, University of Virginia Health System, 400 Ray C. Hunt, Charlottesville, VA 22908, USA.

出版信息

Spine J. 2011 Oct;11(10):e1-6. doi: 10.1016/j.spinee.2011.09.004.

Abstract

BACKGROUND CONTEXT

Discitis or epidural abscess after discogram is a rare but known complication. It is more commonly bacterial; however, fungal discitis has been previously reported in immunocompromised patients. The management of fungal discitis in immunocompetent patients is rarely presented or addressed in the literature.

PURPOSE

To present a rare atypical fungal discitis after routine discogram with a typical presentation in an immunocompetent host, review diagnostic and management guidelines for discitis, and provide recommendations for management of atypical discitis in immunocompetent patients.

STUDY DESIGN

Case report and review of the literature.

METHODS

A 40-year-old woman presented with a 3-week history of progressively worsening low back pain after a lumbar discogram. Magnetic resonance imaging revealed L3-L4 discitis without an epidural abscess. Left L3 and L4 hemilaminectomies with L3-L4 discectomy were performed. An inflammatory mass was seen in the L3-L4 disc space region extending to the left L3 foramen.

RESULTS

Culture specimens obtained during surgery from both the disc and epidural space speciated to Candida lusitaniae. The patient completed a 6-month course of fluconazole therapy. At 2-year follow-up, she continued to be asymptomatic, without any recurrence of infection or neurologic sequelae.

CONCLUSIONS

We report a case of C. lusitaniae spondylodiscitis after discography in an immunocompetent patient with long-term follow-up. Clinicians must maintain a high index of suspicion for discitis in patients who undergo this procedure. If discitis is suspected, culture specimens must be evaluated for fungal and mycobacterial organisms, even in the immunocompetent host. With proper surveillance, surgical intervention, and appropriate postoperative follow-up, this complication can be effectively managed with excellent long-term outcome.

摘要

背景

椎间盘造影术后椎间盘炎或硬膜外脓肿是一种罕见但已知的并发症。它通常是细菌性的;然而,免疫功能低下的患者以前曾报告过真菌性椎间盘炎。免疫功能正常患者的真菌性椎间盘炎的治疗在文献中很少被提出或讨论。

目的

报告一例免疫功能正常患者在常规椎间盘造影术后罕见的非典型真菌性椎间盘炎,表现典型,复习椎间盘炎的诊断和治疗指南,并为免疫功能正常患者的非典型椎间盘炎的治疗提供建议。

研究设计

病例报告和文献复习。

方法

一名 40 岁女性在腰椎间盘造影后 3 周出现进行性加重的下腰痛。磁共振成像显示 L3-L4 椎间盘炎无硬膜外脓肿。行左侧 L3 和 L4 半椎板切除术和 L3-L4 椎间盘切除术。在 L3-L4 椎间盘间隙区域可见炎症性肿块,延伸至左侧 L3 椎间孔。

结果

术中从椎间盘和硬膜外间隙获得的培养标本鉴定为葡萄牙念珠菌。患者完成了 6 个月的氟康唑治疗。2 年随访时,患者继续无症状,无感染或神经后遗症复发。

结论

我们报告了一例免疫功能正常患者椎间盘造影术后葡萄牙念珠菌性脊椎炎病例,并进行了长期随访。如果怀疑椎间盘炎,即使在免疫功能正常的患者中,也必须对培养标本进行真菌和分枝杆菌的评估。通过适当的监测、手术干预和适当的术后随访,这种并发症可以得到有效治疗,长期预后良好。

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