Department of Nuclear Medicine and PET Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Kaohsiung J Med Sci. 2011 Nov;27(11):528-31. doi: 10.1016/j.kjms.2011.06.018. Epub 2011 Sep 8.
Integrated (18)F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG PET/CT) has been clinically used to detect infectious lesions. We present a case with pyrexia and bacteremia of unknown origin. Whole body FDG PET/CT was arranged to look for an occult source of infection and it revealed a focal lesion with increased FDG uptake in the mitral valve area. Under suspicion of infective endocarditis, transthoracic echocardiography was repeated and then the presence of linear vegetation over the calcified mitral annulus was confirmed. Ultimately, definite infective endocarditis was diagnosed according to the Duke criteria. The patient recovered after the antibiotic therapy. In our case, FDG PET/CT can help to localize the exact site of occult infection, thereby guiding additional testing and facilitating timely definitive diagnosis and therapy.
正电子发射断层扫描/计算机断层扫描（PET/CT）已在临床上用于检测感染性病变。我们报告了一例原因不明的发热和菌血症患者。为寻找隐匿性感染源，行全身氟代脱氧葡萄糖（FDG）PET/CT 检查，结果显示二尖瓣区局灶性病变，FDG 摄取增加。考虑感染性心内膜炎的可能性，遂重复经胸超声心动图检查，结果显示钙化二尖瓣环上有线性赘生物。最终，根据 Duke 标准诊断为明确的感染性心内膜炎。经抗生素治疗后，患者痊愈。在本例中，FDG PET/CT 有助于定位隐匿性感染的确切部位，从而指导进一步检查，有助于及时明确诊断和治疗。
