Department of Animal Science, University of Padua, Viale dell'Università 16, 35020 Legnaro, Padua, Italy.
Br J Nutr. 2011 Oct;106 Suppl 1:S120-3. doi: 10.1017/S0007114511004107.
The effects of the dietary inclusion of two levels of short-chain fructooligosaccharides (sc-FOS) on weight loss, biochemical parameters and serum haptoglobin concentration were investigated in twelve experimental obese Beagle dogs. Dogs were randomised into two groups and submitted to a weight loss program (WLP): the control group (C) received a commercial energy-restricted high-protein diet containing 1 % DM sc-FOS, whereas the test group (T) received the same diet enriched with sc-FOS to attain a 3 % DM content. Body weight (BW) and body condition score were weekly assessed in each dog and blood was collected before and after WLP to measure total plasma cholesterol (CHOL), TAG, NEFA, glucose (GLUC), insulin, serum leptin and haptoglobin. Groups showed similar BW and blood parameters before treatment. When values before and after treatment of the dogs were compared, significant reductions were observed for all parameters, with the exception of NEFA and GLUC. However, when these reductions were compared between C and T groups, significant differences were detected only for haptoglobin (T before v. T after: 1545 v. 605 mg/l, P = 0.03; C before v. C after: 1635 v. 1400 mg/l, P = NS). Positive correlations between haptoglobin and CHOL and between haptoglobin and TAG were observed before but not after WLP. In conclusion, feeding obese dogs with the energy-restricted diet caused significant weight loss and reduction of blood parameters, irrespective of the sc-FOS content included. However, serum haptoglobin level, and the subclinical inflammatory condition associated with it, was significantly lowered in the T but not in the C group.
在 12 只实验性肥胖比格犬中，研究了两种水平的短链果聚糖（sc-FOS）的饮食添加对减肥、生化参数和血清触珠蛋白浓度的影响。狗被随机分为两组，并进行减肥计划（WLP）：对照组（C）接受含有 1%DM sc-FOS 的商业能量限制高蛋白饮食，而试验组（T）接受相同的饮食，富含 sc-FOS，以达到 3%DM 含量。每周评估每只狗的体重（BW）和身体状况评分，并在 WLP 前后采集血液，以测量总血浆胆固醇（CHOL）、TAG、NEFA、葡萄糖（GLUC）、胰岛素、血清瘦素和触珠蛋白。治疗前两组的 BW 和血液参数相似。当比较狗治疗前后的值时，所有参数均观察到显著降低，除了 NEFA 和 GLUC。然而，当比较 C 和 T 两组之间的这些降低时，仅检测到触珠蛋白有显著差异（T 治疗前比 T 治疗后：1545 比 605mg/L，P=0.03；C 治疗前比 C 治疗后：1635 比 1400mg/L，P=NS）。治疗前观察到触珠蛋白与 CHOL 之间以及触珠蛋白与 TAG 之间呈正相关，但治疗后则没有。结论：无论包含的 sc-FOS 含量如何，给肥胖狗喂食能量限制饮食都会导致体重显著减轻和血液参数降低。然而，血清触珠蛋白水平及其相关的亚临床炎症状态在 T 组中显著降低，但在 C 组中则没有。
