Department of Cardiovasology, Affiliated Hospital, Binzhou Medical College, Binzhou, China.
Cell Biochem Biophys. 2012 Jan;62(1):87-90. doi: 10.1007/s12013-011-9264-7.
To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.
探讨阿托伐他汀对脑出血（ICH）大鼠脑积水、神经细胞凋亡及血浆基质金属蛋白酶-9（MMP-9）水平的影响。采用胶原酶脑内注射法建立 ICH 大鼠模型。通过干湿重比值法测定脑含水量，电镜观察脑组织超微结构变化，ELISA 法定量测定血浆 MMP-9 水平。阿托伐他汀可显著降低 ICH 大鼠脑含水量、抑制神经元凋亡、降低血浆 MMP-9 水平。血浆 MMP-9 与脑含水量呈正线性相关。阿托伐他汀可显著减轻脑水肿，减少 MMP-9 引起的脑损伤，对 ICH 大鼠神经元起保护作用。
