Platte P, Jaschke H, Herbert C, Korenke G C
Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg,Würzburg, Germany.
Neuropediatrics. 2011 Oct;42(5):179-82. doi: 10.1055/s-0031-1287841. Epub 2011 Oct 17.
The aim of this study was to determine the body composition and resting metabolic rate (RMR) of girls with Rett syndrome (RS) (n=15) and to compare them with an equally handicapped group of girls with developmental disabilities (DD) (n=13). Body composition was measured by bioelectrical impedance analysis and RMR - the amount of energy expended while at rest - by indirect calorimetry. Weight, height, body mass index (BMI), BMI percentiles and food intake were all measured and calculated by standardized procedures. Feeding time, ambulatory status and ability to self-feed were also assessed. Due to the sampling, there were no significant differences in age, height, weight, BMI, BMI percentiles and ambulatory status. Significant differences between groups were found for lower percentage lean body mass (LBM) (64.2±14.6 vs. 84.4±24.6) and higher absolute and relative fat mass (FM) in RS. RMR values adjusted for LBM were significantly higher in the group of girls with RS (approximately 160 kcal/day), indicating that higher energy expenditure is a component of increased risk of severely low body weight.
本研究的目的是确定雷特综合征（RS）女孩（n = 15）的身体成分和静息代谢率（RMR），并将其与同等残疾程度的发育障碍（DD）女孩组（n = 13）进行比较。通过生物电阻抗分析测量身体成分，通过间接量热法测量RMR（静息时消耗的能量）。体重、身高、体重指数（BMI）、BMI百分位数和食物摄入量均通过标准化程序进行测量和计算。还评估了喂食时间、行走状态和自我喂食能力。由于抽样原因，两组在年龄、身高、体重、BMI、BMI百分位数和行走状态方面无显著差异。研究发现，RS组的瘦体重（LBM）百分比更低（64.2±14.6 vs. 84.4±24.6），绝对和相对脂肪量（FM）更高，两组之间存在显著差异。根据LBM调整后的RMR值在RS女孩组中显著更高（约160千卡/天），表明较高的能量消耗是严重低体重风险增加的一个因素。
