Tian Xinrui, Liu Zhuola, Niu Bo, Zhang Jianlin, Tan Thian Kui, Lee So Ra, Zhao Ye, Harris David C H, Zheng Guoping
Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, NSW 2145, Australia.
J Biomed Biotechnol. 2011;2011:567305. doi: 10.1155/2011/567305. Epub 2011 Oct 11.
E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
E-钙黏蛋白/β-连环蛋白复合物在维持上皮完整性方面发挥着重要作用,破坏该复合物不仅会影响细胞的黏附功能,还会影响Wnt信号通路。该复合物的异常表达与多种人类恶性肿瘤以及上皮-间质转化导致的纤维化疾病相关。这些关联揭示了可能导致E-钙黏蛋白/β-连环蛋白具有纤维化/肿瘤抑制作用的复杂性。