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石棉会导致肿瘤免疫力下降。

Asbestos induces reduction of tumor immunity.

作者信息

Kumagai-Takei Naoko, Maeda Megumi, Chen Ying, Matsuzaki Hidenori, Lee Suni, Nishimura Yasumitsu, Hiratsuka Junichi, Otsuki Takemi

机构信息

Department of Hygiene, Kawasaki Medical School, Matsushima, Kurashiki, Japan.

出版信息

Clin Dev Immunol. 2011;2011:481439. doi: 10.1155/2011/481439. Epub 2011 Oct 4.

DOI:10.1155/2011/481439
PMID:22007251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3189469/
Abstract

Asbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced cancers. For example, there is uncertainty concerning the degree of danger of the iron-absent chrysotile compared with iron-containing crocidolite and amosite. However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. We have been investigating the immunological effects of asbestos in relation to the reduction of tumor immunity. In this paper, cellular and molecular approaches to clarify the immunological effects of asbestos are described, and all the findings indicate that the reduction of tumor immunity is caused by asbestos exposure and involvement in asbestos-induced cancers. These investigations may not only allow the clear recognition of the biological effects of asbestos, but also present a novel procedure for early detection of previous asbestos exposure and the presence of mesothelioma as well as the chemoprevention of asbestos-related cancers.

摘要

石棉相关癌症，如恶性间皮瘤和肺癌，是全球范围内的一个重要问题。对于这些癌症，在经济考量和医学证据方面存在诸多冲突，而且石棉诱发癌症的病理机制细节也存在很多混淆之处。例如，与含铁的青石棉和铁石棉相比，不含铁的温石棉的危险程度尚不确定。然而，鉴于间皮瘤预后不良，确保认识石棉的生物学效应和石棉诱发癌变的病理机制的医学方法，以及检测间皮瘤早期阶段的临床试验，应该会带来更好的预防措施并治愈这些恶性肿瘤。我们一直在研究石棉与肿瘤免疫降低相关的免疫效应。本文描述了阐明石棉免疫效应的细胞和分子方法，所有研究结果均表明肿瘤免疫降低是由石棉暴露以及石棉诱发癌症所致。这些研究不仅可以使人们清楚认识石棉的生物学效应，还能为早期检测既往石棉暴露、间皮瘤的存在以及石棉相关癌症的化学预防提供一种新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/d37ac83c54d6/CDI2011-481439.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/4c24482d803a/CDI2011-481439.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/d544967623c6/CDI2011-481439.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/7b269a57c912/CDI2011-481439.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/d37ac83c54d6/CDI2011-481439.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/4c24482d803a/CDI2011-481439.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/d544967623c6/CDI2011-481439.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/7b269a57c912/CDI2011-481439.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b4/3189469/d37ac83c54d6/CDI2011-481439.004.jpg

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本文引用的文献

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Pathol Int. 2011 Jun;61(6):331-44. doi: 10.1111/j.1440-1827.2011.02666.x. Epub 2011 May 2.
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Iron as a target of chemoprevention for longevity in humans.铁作为人类长寿的化学预防靶点。
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CTLA4 blockade in mesothelioma: finally a competing strategy over cytotoxic/target therapy?CTLA4 阻断在间皮瘤中的应用：最终成为细胞毒/靶向治疗的竞争策略？
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Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice.曲拉通 X-100 诱导 C57BL/6 小鼠产生自身抗体和白细胞介素 17。
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Amphibole, but not chrysotile, asbestos induces anti-nuclear autoantibodies and IL-17 in C57BL/6 mice.闪石石棉而非温石棉可诱导C57BL/6小鼠产生抗核自身抗体和白细胞介素-17。
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