Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Org Lett. 2011 Nov 18;13(22):5964-7. doi: 10.1021/ol202381m. Epub 2011 Oct 18.
An efficient synthesis of NP25302 is presented that relies on 5-endo-dig N-cyclization to establish the bicyclic core and Curtius rearrangement to install the N-acyl vinylogous urea functionality.
现提出一种高效合成 NP25302 的方法，该方法依赖于 5-endo-环化 N 来构建双环核心，并通过 Curtius 重排来引入 N-酰基烯基脲官能团。
