新型氮杂螺[3.4]辛烷作为药物发现中的多功能模块的合成。
Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery.
机构信息
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
出版信息
Org Lett. 2011 Nov 18;13(22):6134-6. doi: 10.1021/ol2025313. Epub 2011 Oct 18.
PMID:22007769
Abstract
Step-economic and scalable syntheses of novel thia-azaspiro[3.4]octanes are reported. These spirocycles and some related intermediates can serve as uncharted multifunctional modules for drug discovery chemistry.
摘要
报告了新型硫代氮杂螺[3.4]辛烷的分步经济性和可扩展性合成。这些螺环化合物和一些相关的中间体可以作为药物发现化学中未开发的多功能模块。
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