Bui T, Christin-Maitre S
Endocrinologie de la Reproduction, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, Paris, France.
Ann Endocrinol (Paris). 2011 Oct;72 Suppl 1:S23-8. doi: 10.1016/S0003-4266(11)70006-3.
Vitamin D plays a key role in calcium-phosphorus homeostasis and bone metabolism, but it is also involved in numerous others tissues. Vitamin D deficiency among pregnant women is frequent in many populations over the world. It is associated with an increased risk of preeclampsia, gestational diabetes mellitus, and caesarean section. Consequences in newborns are low birth weight, neonatal rickets, a risk of neonatal hypocalcemia, asthma and/or type 1 diabetes. Therefore, prevention of vitamin D deficiency among pregnant women is essential. The currently recommended supplementation amount of vitamin D is not sufficient to maintain a value of 25 hydroxy vitamin D above 30 ng/ml, during pregnancy. Randomized controlled trials during pregnancy are necessary to evaluate the amount of vitamin D sufficient to avoid the consequences of vitamin D deficiency.
维生素D在钙磷稳态和骨代谢中起关键作用，但它也参与许多其他组织的生理过程。全球许多人群中，孕妇维生素D缺乏的情况很常见。它与子痫前期、妊娠期糖尿病和剖宫产风险增加有关。对新生儿的影响包括低出生体重、新生儿佝偻病、新生儿低钙血症风险、哮喘和/或1型糖尿病。因此，预防孕妇维生素D缺乏至关重要。目前推荐的维生素D补充量不足以在孕期将25羟维生素D水平维持在30 ng/ml以上。孕期进行随机对照试验对于评估足以避免维生素D缺乏后果的维生素D补充量很有必要。
