Jalil R, Nixon J R
Chelsea Department of Pharmacy, King's College London, University of London.
J Microencapsul. 1990 Jul-Sep;7(3):297-325. doi: 10.3109/02652049009021842.
Poly(lactic acid) [PLA] and its co-polymers with glycolic acid [PLCG] have been known to be biodegradable and histocompatible for the past 20 years. Their physico-chemical and biological properties have been found suitable, in many instances, for sustaining drug release in vivo for days or months. Several dosage forms for parenteral administration have been investigated using these polymers and a microencapsulation technique is chosen frequently for its unique properties. There are a limited number of published papers concerning preparation and characterization of PLA or PLCG microcapsules, possibly because of commercial unavailability and difficulties in the synthesis of reproducible batches of these polymers. However, microcapsules can be made using different traditional and non-traditional techniques containing core materials ranging from biological proteins to synthetic drugs. An attempt is made here to review problems associated with the different microencapsulation techniques using PLA or PLCG. In vivo and in vitro drug release from these microcapsules is also reviewed.
在过去20年中，聚乳酸（PLA）及其与乙醇酸的共聚物（PLCG）已被公认为具有生物可降解性和组织相容性。在许多情况下，已发现它们的物理化学和生物学特性适合于在体内持续数天或数月释放药物。已经使用这些聚合物研究了几种用于肠胃外给药的剂型，并且由于其独特的特性，微囊化技术经常被选用。关于PLA或PLCG微囊制备和表征的已发表论文数量有限，这可能是因为这些聚合物无法商业化获得且难以合成可重复批次的产品。然而，可以使用不同的传统和非传统技术制备微囊，其核心材料范围从生物蛋白到合成药物。本文试图综述使用PLA或PLCG的不同微囊化技术相关的问题。还综述了这些微囊中药物的体内和体外释放情况。
