Vidmar V, Smolcić-Bubalo A, Jalsenjak I
Faculty of Pharmacy and Biochemistry University of Zagreb, Croatia, Yugoslavia.
J Microencapsul. 1984 Apr-Jun;1(2):131-6. doi: 10.3109/02652048409038517.
Poly(lactic acid) microcapsules of oxytetracycline hydrochloride were prepared by precipitation of the polymer from a solution when a non-solvent was added to a polymer solution in which the drug had been dispersed. Three types of microcapsules were prepared by varying the amount of drug encapsulated, as well as by using two samples of polymer with different molecular weights. The product obtained was of a matrix character consisting of agglomerated capsules. The drug release in vitro, for the best batch, was completed within 12 hours. Serum levels of the drug in rabbits treated by intramuscular injection were prolonged maximally up to 24 hours depending upon the type of microcapsules.
通过向已分散药物的聚合物溶液中加入非溶剂，使聚合物从溶液中沉淀来制备盐酸土霉素的聚（乳酸）微胶囊。通过改变包封药物的量以及使用两种不同分子量的聚合物样品制备了三种类型的微胶囊。所得产物具有由团聚胶囊组成的基质特征。对于最佳批次，体外药物释放在12小时内完成。根据微胶囊的类型，肌肉注射治疗的家兔体内药物血清水平最长可延长至24小时。
