睾酮替代疗法与 HIV 感染患者的红细胞增多症。
Testosterone replacement therapy and polycythemia in HIV-infected patients.
机构信息
Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
出版信息
AIDS. 2012 Jan 14;26(2):243-5. doi: 10.1097/QAD.0b013e32834db446.
Abstract
We conducted a case-control study to assess testosterone use as a primary risk factor for polycythemia in 21 HIV-infected men. Any testosterone use within 2 months of first elevated hemoglobin was associated with polycythemia (matched odds ratio 6.55; 95% confidence interval 1.83-23.4; P = 0.004) and intramuscular administration demonstrated a stronger association than topical use. No adverse cardiovascular or thrombotic events were observed. HIV-infected patients taking testosterone should undergo routine hematologic monitoring with adjustment of therapy when appropriate.
摘要
我们进行了一项病例对照研究，以评估睾酮使用是否为 21 名 HIV 感染男性中红细胞增多症的主要危险因素。首次血红蛋白升高后 2 个月内任何睾酮使用均与红细胞增多症相关（匹配比值比 6.55；95%置信区间 1.83-23.4；P=0.004），且肌肉内给药与外用给药相比具有更强的相关性。未观察到不良心血管或血栓形成事件。正在接受睾酮治疗的 HIV 感染患者应进行常规血液学监测，并在适当情况下调整治疗。
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