Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA.
AAPS PharmSciTech. 2011 Dec;12(4):1393-400. doi: 10.1208/s12249-011-9715-x. Epub 2011 Oct 19.
Microdermabrasion is widely used as a non-invasive cosmetic technique that has recently been adapted to selectively remove stratum corneum to increase skin permeability for transdermal drug delivery. This study measured the kinetics of skin barrier recovery after stratum corneum removal using microdermabrasion in hairless guinea pigs. The skin was abraded at two sites on each animal, one of which was allowed to recover under occlusion while the other remained non-occluded. Histological measurements showed that skin barrier properties to sulforhodamine B largely recovered within 12 h, and the stratum corneum appeared largely reformed within 24 h for both occluded and non-occluded skin. Skin electrical resistance measurements showed significant recovery of the skin barrier within 24 h. We conclude that transdermal drug delivery may occur for up to 12 h after microdermabrasion in guinea pigs; however, humans will probably have a longer recovery time due to expected slower skin healing rates.
微晶磨皮术被广泛应用于一种非侵入性的美容技术，最近已被用于选择性去除角质层，以增加皮肤通透性，从而实现经皮药物传递。本研究通过对无毛豚鼠进行微晶磨皮术，测量角质层去除后皮肤屏障恢复的动力学。在每个动物的两个部位进行皮肤研磨，其中一个部位用闭塞法覆盖以使其恢复，而另一个部位保持非闭塞状态。组织学测量显示，磺基罗丹明 B 的皮肤屏障性能在 12 小时内基本恢复，并且对于闭塞和非闭塞皮肤，在 24 小时内角质层基本重新形成。皮肤电阻测量显示，皮肤屏障在 24 小时内得到显著恢复。我们的结论是，豚鼠在微晶磨皮后长达 12 小时内可能会发生经皮药物传递；然而，由于预期皮肤愈合速度较慢，人类可能需要更长的恢复时间。
