局部和透皮药物递送：从简单的药水到智能技术。

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Australia.

Diamantina Institute, The University of Queensland, Translational Research Institute, QLD, 4102, Australia.

Curr Drug Deliv. 2019;16(5):444-460. doi: 10.2174/1567201816666190201143457.

This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

本文概述了皮肤给药的发展历程，从远古时代至今，介绍了经皮吸收原理和皮肤制剂的发展历程。自古以来，人们就认识到可以将产品应用于皮肤以实现局部或全身效果。随着我们对皮肤解剖结构和生理学的认识不断提高，这促进了各种技术的发展，这些技术可将溶质有效地递送至皮肤的特定靶位和靶位以外的区域，从而实现定量输送。本文重点介绍了这些技术及其在当今和未来皮肤给药中的作用。