Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
J Antimicrob Chemother. 2012 Jan;67(1):4-11. doi: 10.1093/jac/dkr437. Epub 2011 Oct 18.
Fifty years ago methicillin-resistant Staphylococcus aureus (MRSA) first revealed themselves to the medical community, having been described in a landmark article published in the British Medical Journal. Among other things, their discovery set off a major response from the scientific and medical professions to control or even eliminate them as major human pathogens. Despite these efforts, however, MRSA have spread throughout the world and a half century after they burst upon the scene they continue to pose major challenges to research scientists and clinicians alike. In a very real sense, this year marks the 'birthday' of a remarkably successful pathogen. The major reasons for the ability of MRSA to prosper and cause disease in settings inimical to its survival form the basis of this article.
五十年前，耐甲氧西林金黄色葡萄球菌 (MRSA) 在英国医学杂志上发表的一篇具有里程碑意义的文章中首次向医学界揭示了自己的存在。除其他外，它们的发现引发了科学界和医学界的重大反应，旨在控制甚至消除它们作为主要人类病原体的地位。然而，尽管做出了这些努力，MRSA 还是已经在世界各地传播开来，在它们出现半个世纪后，它们仍然对研究科学家和临床医生构成重大挑战。从某种意义上说，今年标志着一种非常成功的病原体的“生日”。MRSA 能够在不利于其生存的环境中茁壮成长并引起疾病的主要原因是本文的基础。
