Ardila Carlos M, López Mayra A, Guzmán Isabel C
Epidemiology Group, University of Antioquia, Colombia.
Acta Odontol Latinoam. 2011;24(1):15-9.
The association between Gram negative enteric rods and Porphyromonas gingivalis in periodontal diseases has received little attention in the literature. Thus, the aim of this study was to investigate the associations between Gram negative enteric rods, Porphyromonas gingivalis and clinical parameters of periodontal disease. The prevalence of Gram-negative enteric rods and P. gingivalis were examined in patients with chronic periodontitis. Chi-square and Mann-Whitney tests were used to determine differences in clinical variables versus the presence or absence of both microorganisms. Correlations of both organisms and clinical data were determined using Spearman rank correlation coefficient. Gram-negative enteric rods and P. gingivalis were detected in 20 (26.3%) and 51 (67.1%) subjects, respectively. A total 17 (22.4%) individuals harbored both microorganisms studied. There were significantly positive correlations between enteric rods and presence of P. gingivalis (r=0.531, P<.0001). Both microorganisms were significantly and positively correlated with probing depth, clinical attachment level and bleeding on probing (P<0.0001). The mean probing depth (mm) of the sampled sites was significantly deeper in patients with presence of P. gingivalis and Gram-negative enteric rods. This study suggests that the presence of Gram negative enteric rods and P. gingivalis is related to adverse periodontal conditions. These results could have an impact on periodontal treatment and should be taken into account in the mechanical and antimicrobial treatment of periodontal disease in some populations.
革兰氏阴性肠道杆菌与牙龈卟啉单胞菌在牙周疾病中的关联在文献中很少受到关注。因此，本研究的目的是调查革兰氏阴性肠道杆菌、牙龈卟啉单胞菌与牙周疾病临床参数之间的关联。对慢性牙周炎患者检测革兰氏阴性肠道杆菌和牙龈卟啉单胞菌的患病率。采用卡方检验和曼-惠特尼检验来确定临床变量与两种微生物存在与否之间的差异。使用斯皮尔曼等级相关系数确定两种微生物与临床数据之间的相关性。分别在20名（26.3%）和51名（67.1%）受试者中检测到革兰氏阴性肠道杆菌和牙龈卟啉单胞菌。共有17名（22.4%）个体同时携带所研究的两种微生物。肠道杆菌与牙龈卟啉单胞菌的存在之间存在显著正相关（r = 0.531，P <.0001）。两种微生物均与探诊深度、临床附着水平和探诊出血显著正相关（P < 0.0001）。在存在牙龈卟啉单胞菌和革兰氏阴性肠道杆菌的患者中，采样部位的平均探诊深度（mm）明显更深。本研究表明，革兰氏阴性肠道杆菌和牙龈卟啉单胞菌的存在与不良牙周状况有关。这些结果可能会对牙周治疗产生影响，在某些人群的牙周疾病机械治疗和抗菌治疗中应予以考虑。
