Gawlikowski Tomasz, Szpak Dorota, Balicka-Slusarczyk Barbara, Wilimowska Jolanta, Gomółka Ewa
Klinika Toksykologii i Chorób Srodowiskowych, Uniwersytet Jagielloński, Collegium Medicum w Krakowie.
Przegl Lek. 2011;68(8):434-5.
18 patients with acute clozapine poisoning, 6 female and 12 male, were analyzed. The mean age was 42.8 years. Six patients were intoxicated only clozapine. Mixed poisoning (clozapine and other factor) was diagnosed in nine cases. Among the additional factors dominated psychotropic drugs. According to the Poisoning Severity Score (PSS) criteria in the study group was only a one mild intoxication. Acute pneumonia developed in 3 patients, acute bronchitis and rabdomyolysis were reported in one case. The most common symptoms included: agitation, confusion (83.3%), tachycardia (77.8%), CNS depression (66.7%), excessive mucus production in bronchi, hypersalivation (44.4%), miosis (50%). Disordered breathing requiring intubation or mechanical ventilation occurred in 27.7% of poisoned. The average duration of hospitalization was less than 7 days.
对18例急性氯氮平中毒患者进行了分析，其中女性6例，男性12例。平均年龄为42.8岁。6例患者仅为氯氮平中毒。9例诊断为混合中毒（氯氮平与其他因素）。在其他因素中，精神药物占主导。根据中毒严重程度评分（PSS）标准，研究组仅1例轻度中毒。3例患者发生急性肺炎，1例报告有急性支气管炎和横纹肌溶解。最常见的症状包括：躁动、意识模糊（83.3%）、心动过速（77.8%）、中枢神经系统抑制（66.7%）、支气管黏液分泌过多、流涎过多（44.4%）、瞳孔缩小（50%）。27.7%的中毒患者出现需要插管或机械通气的呼吸紊乱。平均住院时间少于7天。
