Department of Nutrition, Euro American Institute of Education, Science and Technology, Brasilia, Brazil.
Scand J Immunol. 2012 Mar;75(3):336-41. doi: 10.1111/j.1365-3083.2011.02656.x.
There is scientific evidence to suggest that the medicinal mushroom Agaricus blazei Murrill (AbM) has immunomodulatory effects on cytokine synthesis, both in vitro and in vivo. This study was the first randomized, double-blind, placebo-controlled trial designed to investigate these purported actions in elderly women. The objective of this study was to ascertain the effects of AbM intake on serum levels of interleukin-6 (IL-6), interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) in community-living seniors. The sample consisted of 57 elderly females who were carriers or homozygous for the majority allele of functional polymorphisms for the chosen cytokines. Subjects were randomly allocated to receive placebo (n = 29) or AbM dry extract (n = 28), 900 mg/day for 60 days. Body mass index, abdominal girth, body composition, blood pressure and cytokine (IL-6, IFN-γ, and TNF-α) levels were measured, and food intake was assessed as a possible confounder. Analysis of these parameters showed the sample was characterized by overweight and excess adiposity. After the study period, no changes from baseline were detectable for any parameter in either group. In this study, AbM extract had no modulating effect on IL-6, IFN-γ or TNF-α levels in elderly females.
有科学证据表明，药用蘑菇姬松茸（AbM）在体外和体内对细胞因子的合成具有免疫调节作用。这项研究是首次设计用于调查老年女性中这些所谓作用的随机、双盲、安慰剂对照试验。本研究的目的是确定 AbM 摄入对社区居住的老年人血清白细胞介素-6（IL-6）、干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）水平的影响。该样本由 57 名携带或纯合选择细胞因子功能多态性的大多数等位基因的老年女性组成。受试者随机分为接受安慰剂（n = 29）或 AbM 干提取物（n = 28），每天 900 毫克，持续 60 天。测量体重指数、腰围、身体成分、血压和细胞因子（IL-6、IFN-γ 和 TNF-α）水平，并评估食物摄入量作为可能的混杂因素。对这些参数的分析表明，该样本的特征是超重和过多的肥胖。在研究期间，两组的任何参数均未从基线开始发生变化。在这项研究中，AbM 提取物对老年女性的 IL-6、IFN-γ 或 TNF-α 水平没有调节作用。
