Graduate Program in Physical Education and Health, Catholic University of Brasília, Brasília, Brazil.
Neuroimmunomodulation. 2011;18(3):165-70. doi: 10.1159/000323396. Epub 2011 Feb 9.
The increase in inflammatory activity associated with aging is a characteristic of chronic disease processes that accounts for most of the mortality in the elderly. Resistance training (RT) has been shown to promote metabolic and functional benefits in this population. The objective of this study was to investigate the association between long-term RT and circulating levels of the proinflammatory mediators IL-6, TNF-α and IFN-γ in elderly women.
This cross-sectional study included 54 older outpatients divided into a group that underwent RT (n = 28) for an average of 8.6 ± 0.3 months and a sedentary group (n = 26). Measurements were taken only at the end of the intervention, and cytokine values were log-transformed. Dietary intake was controlled as a confounding factor.
The RT group presented reduced levels of log₁₀IFN-γ (approx. 45%; p = 0.003), log₁₀IL-6 (approx. 30%; p = 0.002) and log₁₀TNF-α (approx. 22%; p = 0.036). Total caloric intake and systolic arterial blood pressure were significantly lower in the RT group (p = 0.001 and p = 0.022, respectively). Pearson's product moment correlation test revealed a negative association between the fat-free mass (FFM) index and log-transformed IL-6 levels (p = 0.03; n = 54) and a trend towards significance for the correlation between the FFM index and log₁₀IFN-γ (p = 0.05; n = 54).
Long-term, moderate-intensity RT in elderly women is associated with lower circulating levels of cytokines that are potentially implicated in disorders associated with physical inactivity and aging.
与衰老相关的炎症活动增加是慢性疾病过程的特征，这也是老年人死亡的主要原因。阻力训练（RT）已被证明可促进该人群的代谢和功能益处。本研究的目的是研究长期 RT 与老年女性循环中促炎介质 IL-6、TNF-α 和 IFN-γ 水平之间的关系。
这项横断面研究包括 54 名年龄较大的门诊患者，分为进行 RT（n = 28）的组，平均进行 8.6 ± 0.3 个月，以及久坐不动的组（n = 26）。仅在干预结束时进行测量，并对细胞因子值进行对数转换。控制饮食摄入作为混杂因素。
RT 组 IFN-γ（约 45%；p = 0.003）、IL-6（约 30%；p = 0.002）和 TNF-α（约 22%；p = 0.036）的 log₁₀ 水平降低。RT 组的总热量摄入和收缩压明显降低（p = 0.001 和 p = 0.022）。Pearson 积矩相关检验显示，去脂体重（FFM）指数与 log 转换后的 IL-6 水平呈负相关（p = 0.03；n = 54），FFM 指数与 log₁₀IFN-γ 之间的相关性有统计学意义（p = 0.05；n = 54）。
在老年女性中进行长期、中等强度的 RT 与循环中潜在与缺乏身体活动和衰老相关的疾病有关的细胞因子水平降低有关。
