Bauer Kimberly A, Brimhall Angela K, Chang Timothy T
Department of Dermatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Department of Dermatology, Case Western Reserve University, University Hospitals, Cleveland, Ohio.
Pediatr Dermatol. 2011 Nov-Dec;28(6):741-743. doi: 10.1111/j.1525-1470.2011.01558.x. Epub 2011 Oct 20.
We report the first pediatric case of drug reaction with eosinophilia and systemic symptoms associated with azithromycin use in the setting of acute Epstein-Barr virus infection in an 8-year-old boy. Our patient presented with fever, cutaneous eruption, eosinophilia, and hypotension requiring intensive care unit admission. He was discharged in good condition without any long-term sequelae. This case underscores the importance of timely and accurate diagnosis of acute viral infections and appropriate use of antibiotics as well as recognition of the clinical signs of drug reaction with eosinophilia and systemic symptoms.
我们报告了首例8岁男孩在急性爱泼斯坦-巴尔病毒感染情况下使用阿奇霉素后出现药物反应伴嗜酸性粒细胞增多和全身症状的儿科病例。我们的患者出现发热、皮疹、嗜酸性粒细胞增多和低血压，需要入住重症监护病房。他出院时情况良好，没有任何长期后遗症。该病例强调了及时准确诊断急性病毒感染、合理使用抗生素以及识别药物反应伴嗜酸性粒细胞增多和全身症状临床体征的重要性。
