儿童药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）
Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.
作者信息
Mori Francesca, Caffarelli Carlo, Caimmi Silvia, Bottau Paolo, Liotti Lucia, Franceschini Fabrizio, Cardinale Fabio, Bernardini Roberto, Crisafulli Giuseppe, Saretta Francesca, Novembre Elio
机构信息
Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children's University Hospital, Florence, Italy.
出版信息
Acta Biomed. 2019 Jan 29;90(3-S):66-79. doi: 10.23750/abm.v90i3-S.8167.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved both in adults and in children. The treatment of choice is intravenous immunoglobulins and corticosteroids used in synergy. Today there are not controlled clinical trials regarding DRESS treatment in children. Anyway, the prompt withdrawn of the offending drug is of paramount importance for a better prognosis. DRESS sequels may occur, consequently, follow-up visits are required at least until the first year after the reaction.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种严重的药物不良反应。儿童DRESS的发病率尚不清楚，死亡率似乎低于10%。抗惊厥药是成人和儿童中引发该反应的主要药物。治疗的首选是联合使用静脉注射免疫球蛋白和皮质类固醇。目前尚无关于儿童DRESS治疗的对照临床试验。无论如何，迅速停用致病药物对于改善预后至关重要。DRESS可能会有后遗症，因此，至少在反应发生后的第一年需要进行随访。
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