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阿奇霉素输注相关的低血压发作：一种潜在致命的药物不良反应。

Hypotensive episodes associated with azithromycin infusion: a potentially fatal adverse drug reaction.

作者信息

Wong Jeffrey, Munsif Maitri, O'Hehir Robyn, Hew Mark, Dabscheck Eli

机构信息

Department of Respiratory Medicine The Alfred Hospital Melbourne Victoria Australia.

出版信息

Respirol Case Rep. 2019 Aug 5;7(7):e00464. doi: 10.1002/rcr2.464. eCollection 2019 Oct.

DOI:10.1002/rcr2.464
PMID:31406576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6682541/
Abstract

We report the first case of hypotensive episodes associated with intravenous (IV) azithromycin. This is a potentially fatal adverse drug reaction (ADR), with the risk of irreversible end-organ damage, and therefore must be recognized and treated immediately. In our case, the reaction was successfully managed by immediate cessation of the azithromycin infusion. It is important for clinicians to be aware of this ADR as azithromycin is a commonly prescribed medication worldwide.

摘要

我们报告了首例与静脉注射阿奇霉素相关的低血压发作病例。这是一种潜在致命的药物不良反应（ADR），存在不可逆终末器官损伤的风险，因此必须立即识别并治疗。在我们的病例中，通过立即停止阿奇霉素输注，该反应得到了成功处理。由于阿奇霉素是全球常用的处方药，临床医生了解这种ADR非常重要。

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本文引用的文献

1
The Role of Macrolide Antibiotics in Increasing Cardiovascular Risk.大环内酯类抗生素增加心血管风险的作用。
J Am Coll Cardiol. 2015 Nov 17;66(20):2173-2184. doi: 10.1016/j.jacc.2015.09.029.
2
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J Med Case Rep. 2014 Oct 8;8:332. doi: 10.1186/1752-1947-8-332.
3
Clinical and histologic features of azithromycin-induced liver injury.阿奇霉素所致肝损伤的临床及组织学特征。
Clin Gastroenterol Hepatol. 2015 Feb;13(2):369-376.e3. doi: 10.1016/j.cgh.2014.07.054. Epub 2014 Aug 9.
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Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury.钙通道阻滞剂-克拉霉素药物相互作用与急性肾损伤。
JAMA. 2013 Dec 18;310(23):2544-53. doi: 10.1001/jama.2013.282426.
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[DRESS associated with azithromycin in a child].[一名儿童中与阿奇霉素相关的药物反应伴嗜酸粒细胞增多和系统症状（DRESS）]
Ann Dermatol Venereol. 2013 Jan;140(1):75. doi: 10.1016/j.annder.2012.09.006. Epub 2012 Dec 20.
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Calcium channel blockers + macrolides: elderly patients hospitalised for low blood pressure.钙通道阻滞剂 + 大环内酯类药物：因低血压住院的老年患者。
Prescrire Int. 2012 Jul;21(129):182.
7
Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with azithromycin in acute Epstein-Barr virus infection.急性爱泼斯坦-巴尔病毒感染中与阿奇霉素相关的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）
Pediatr Dermatol. 2011 Nov-Dec;28(6):741-743. doi: 10.1111/j.1525-1470.2011.01558.x. Epub 2011 Oct 20.
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The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers.大环内酯类抗生素与钙通道阻滞剂联合使用后低血压的风险。
CMAJ. 2011 Feb 22;183(3):303-7. doi: 10.1503/cmaj.100702. Epub 2011 Jan 17.
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Macrolides and ketolides: azithromycin, clarithromycin, telithromycin.大环内酯类和酮内酯类：阿奇霉素、克拉霉素、泰利霉素。
Infect Dis Clin North Am. 2004 Sep;18(3):621-49, xi-. doi: 10.1016/j.idc.2004.04.010.