Department of Chemistry for Materials, Graduate School of Engineering, Mie University, Tsu, Mie 514-8507, Japan.
J Org Chem. 2011 Dec 2;76(23):9670-7. doi: 10.1021/jo201692x. Epub 2011 Oct 31.
Alkoxycarbonyl iminium species are prepared easily by the oxidation of tetrasubstituted amino ketene silyl acetals, and subsequent nucleophilic addition of Grignard reagents to the iminium salts gives α,α-disubstituted α-amino ester derivatives in moderate to good yields, in which aryl and ethynyl substituents are readily introduced.
烷氧基羰基亚氨基物种可通过四取代氨基烯酮硅基缩醛的氧化容易地制备，并且随后格氏试剂对亚胺盐的亲核加成以中等至良好的收率得到α,α-二取代的α-氨基酯衍生物，其中芳基和乙炔基取代基容易引入。
