Division of Clinical Research, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.
Cancer Invest. 2011 Nov;29(9):635-43. doi: 10.3109/07357907.2011.621911.
Classical prognostic factors of breast cancer are correlated to disease-free survival and overall survival (OS); their precise role is less known on metastatic disease. A total of 511 breast cancer patients without initial metastasis were treated. OS was divided in time to distant recurrence and metastatic survival (MS). Age, Scarff-Bloom-Richardson (SBR) grade, hormone receptor, axillary node involvement, and Nottingham prognostic index predicted MS in univariate analysis. Multivariate analysis retained age, SBR grade, and axillary lymph node involvement as significant independent prognostic factors. Interactions are still present between initial parameters and MS. The clinician has to take into account for treatment choice.
乳腺癌的经典预后因素与无病生存期和总生存期（OS）相关；在转移性疾病中，其确切作用尚不清楚。共有 511 名无初始转移的乳腺癌患者接受了治疗。OS 分为远处复发时间和转移生存时间（MS）。年龄、Scarff-Bloom-Richardson（SBR）分级、激素受体、腋窝淋巴结受累和 Nottingham 预后指数在单因素分析中预测 MS。多因素分析保留了年龄、SBR 分级和腋窝淋巴结受累作为重要的独立预后因素。初始参数与 MS 之间仍存在交互作用。临床医生在选择治疗方案时必须考虑到这些因素。
