Department of Medicine, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Infect Agent Cancer. 2011 Oct 20;6(1):17. doi: 10.1186/1750-9378-6-17.
We present here a case of young male with complaints of fever and swelling in the neck for eight months. History of progressive weakness associated with weight loss was present. Physical examination revealed pallor, multiple enlarged cervical lymph nodes and hepatosplenomegaly. Investigations showed pancytopenia, hyperglobinemia and Leishman-Donovan bodies on bone marrow aspiration. Serological test confirmed diagnosis of visceral leishmaniasis. However, cervical lymph node aspiration and biopsy were suggestive of Mixed cellularity Hodgkin's disease. This made it a very rare case of Leishmaniasis as an opportunistic infection in a patient of pre-chemotherapy Hodgkin's disease. There was marked improvement in haematological profile and regression of hepatosplenomegaly with Amphotericin B treatment followed by favourable response to chemotherapy. The case emphasizes the suspicion for leishmaniasis as a masquerader and as an opportunistic infection in haematological malignancies.
我们在此介绍一例年轻男性病例，其主要症状为发热和颈部肿胀 8 个月。伴有进行性无力和体重减轻的病史。体格检查显示苍白、多个颈淋巴结肿大和肝脾肿大。检查显示全血细胞减少、高球蛋白血症和骨髓抽吸时出现利什曼- Donovan 体。血清学检测证实了内脏利什曼病的诊断。然而，颈淋巴结抽吸和活检提示混合细胞性霍奇金病。这使得它成为一例非常罕见的利什曼病病例，即化疗前霍奇金病患者的机会性感染。两性霉素 B 治疗后，血液学特征明显改善，肝脾肿大消退，随后对化疗有良好反应。该病例强调了在血液系统恶性肿瘤中，应怀疑利什曼病作为伪装者和机会性感染。
