Assistance Publique - Hôpitaux de Paris, Hôpital Bicêtre, Département d'Anesthésie-Réanimation, EA 3509 Université Paris Sud XI, France F-94275, Le Kremlin-Bicêtre, France.
Crit Care. 2011;15(5):194. doi: 10.1186/cc10429. Epub 2011 Oct 4.
Donnino and colleagues provide new insights into the field of oxidative stress and mitochondrial dysfunction during septic shock. These authors suggest a coenzyme Q10 (CoQ10) deficiency in patients with septic shock. Larger prospective observational trials measuring CoQ10 in patients with septic shock are required to confirm the possibility of CoQ10 depletion. This study is a new step toward a study testing CoQ10 as a potential therapeutic agent for patients with septic shock.
多尼诺及其同事深入研究了脓毒性休克期间氧化应激和线粒体功能障碍领域。这些作者提示脓毒性休克患者存在辅酶 Q10（CoQ10）缺乏。需要更大规模的前瞻性观察性试验来测量脓毒性休克患者的 CoQ10 以确认 CoQ10 耗竭的可能性。这项研究是朝着研究 CoQ10 作为脓毒性休克患者潜在治疗剂迈出的新一步。
